Fig. 2
From: CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer
AKT silencing repressed the tumorigenicity of CDK5RAP3 knockdown gastric cancer cells. a-b, d-e) The stimulatory effect of CDK5RAP3 downregulation on AGS and HGC-27 cell proliferation was rescued by AKT siRNA transfection, as shown by both the CCK8 proliferation assay (a, d) and cell counting assay (b, e) (**, P < 0.01; ***, P < 0.001; ns, no significance). (c, f) The stimulatory effect of CDK5RAP3 downregulation on AGS and HGC-27 cell colony formation was rescued by AKT siRNA transfection. The data are presented as the mean ± SD (**, P < 0.05; ns, no significance)