Fig. 4
From: CDK5RAP3 suppresses Wnt/β-catenin signaling by inhibiting AKT phosphorylation in gastric cancer
The clinical value of CDK5RAP3 depends on AKT activity. a The protein levels of CDK5RAP3/AKT/p-AKT (S473)/GSK3β/p-GSK3β (S9) in gastric tumor tissues and adjacent non-tumor tissues from 86 patients were measured by western blotting. The representative results are shown. b There was an inverse correlation between CDK5RAP3 protein level and p-AKT (S473) expression in gastric tumor tissues. c There was an inverse correlation between CDK5RAP3 protein level and p-GSK3β (S9) expression in gastric tumor tissues. d The expression of CDK5RAP3, GSK, p-GSK3β (S9), AKT, p-AKT (S473) protein in gastric tumor tissues and adjacent non-tumor tissues was analyzed using IHC (representative results are shown). e There was an inverse correlation between CDK5RAP3 IHC scoring and p-AKT (S473) expression in gastric tumor tissues. f There was an inverse correlation between CDK5RAP3 protein level and p-GSK3β (S9) expression in gastric tumor tissues