Variables | Univariate Analysis | Multivariate Analysis | ||||
---|---|---|---|---|---|---|
Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |
OGN | Â | Â | Â | Â | Â | Â |
 Low | 1 (reference) |  |  | 1 (reference) |  |  |
 High | 0.609 | 0.378–0.980 | 0.041 | 0.523 | 0.317–0.862 | 0.011 |
Gender | Â | Â | Â | NI | Â | Â |
 Male | 1 (reference) |  |  |  |  |  |
 Female | 0.816 | 0.514–1.296 | 0.389 |  |  |  |
Age, y | 1.017 | 0.997–1.038 | 0.103 | NI |  |  |
TNM stage | Â | Â | Â | Â | Â | Â |
 IV | 1 (reference) |  |  | 1 (reference) |  |  |
 III | 0.227 | 0.141–0.367 | < 0.01 | – | – |  |
 II | 0.063 | 0.029–0.138 | < 0.01 | 0.186 | 0.075–0.461 | < 0.001 |
 I | – | – | 0.957 |  |  | 0.969 |
Grade | Â | Â | Â | NI | Â | Â |
 Well/ moderate | 1 (reference) |  |  |  |  |  |
 poor | 1.265 | 0.805–1.987 | 0.308 |  |  |  |
T stage | Â | Â | Â | Â | Â | Â |
 T2 | 1 (reference) |  |  | 1 (reference) |  |  |
 T3 | 3.927 | 0.860–17.924 | 0.077 | 4.247 | 0.910-19.829 | 0.066 |
 T4 | 9.419 | 2.306–38.469 | 0.002 | 4.258 | 1.022–17.744 | 0.047 |
N stage | Â | Â | Â | Â | Â | Â |
 N0 | 1 (reference) |  |  | 1 (reference) |  |  |
 N1 | 2.635 | 1.456–4.768 | 0.001 | 0.510 | 0.234–1.112 | 0.09 |
 N2 | 3.713 | 2.079–6.633 | < 0.001 | 0.595 | 0.275–1.286 | 0.186 |
M stage | Â | Â | Â | Â | Â | Â |
 M0 | 1 (reference) |  |  | 1 (reference) |  |  |
 M1 | 6.886 | 4.331–10.95 | < 0.001 | 1.314 | 0.522–3.306 | 0.562 |
Lymph node examined | 0.963 | 0.925–1.002 | 0.065 | NI |  |  |
Histological type | Â | Â | Â | NI | Â | Â |
 Adenocarcinoma | 1 (reference) |  |  |  |  |  |
 Mucinous | 0.842 | 0.308-2.304 | 0.738 |  |  |  |
Perineural invasion | Â | Â | Â | Â | Â | Â |
 Negative | 1 (reference) |  |  | 1 (reference) |  |  |
 Positive | 1.798 | 1.061–3.045 | 0.029 | 1.305 | 0.750–2.272 | 0.346 |
Vascular invasion | Â | Â | Â | Â | Â | Â |
 Positive | 1 (reference) |  |  | 1 (reference) |  |  |
 Negative | 0.443 | 0.283–0.692 | < 0.01 | 1.058 | 0.640-1.750 | 0.827 |
Adjuvant CT | Â | Â | Â | Â | Â | Â |
 No | 1 (reference) |  |  | 1 (reference) |  |  |
 Yes | 6.366 | 3.914–10.356 | < 0.01 | 1.945 | 1.228–3.080 | 0.005 |
MS status/MMR status | Â | Â | Â | NI | Â | Â |
 MSS/MMR-proficient | 1 (reference) |  |  |  |  |  |
 MSI/MMR-deficient | 0.946 | 0.599–1.493 | 0.811 |  |  |  |