Table 3 Univariate and Multivariate analyses of prognostic factors for disease free survival

OGN

 Low

1 (reference)

1 (reference)

 High

0.651

0.433–.978

0.627

0.406–0.968

Gender

NI

 Male

1 (reference)

 Female

0.889

0.597–1.326

Age, y

1.014

0.996–1.032

NI

TNM stage

 IV

1 (reference)

1 (reference)

 III

0.216

0.140–0.336

–

–

 II

0.071

0.037–0.136

0.215

0.091–0.510

 I

0.021

0.003–0.157

0.162

0.017–1.542

Grade

NI

 Well/ moderate

1 (reference)

 poor

1.067

0.722–1.575

T stage

 T2

1 (reference)

1 (reference)

 T3

2.790

1.029–7.564

3.753

1.228–11.471

 T4

4.854

1.967–11.979

3.139

1.127–8.744

N stage

 N0

1 (reference)

1 (reference)

 N1

2.608

1.582–4.298

0.689

0.343–1.383

 N2

3.328

2.026–5.466

0.701

0.348–1.412

M stage

 M0

1 (reference)

1 (reference)

 M1

6.907

4.517–10.561

3.071

1.316–7.168

Lymph node examined

0.954

0.922–0.988

0.961

0.926–0.997

Histological type

NI

 Adenocarcinoma

1 (reference)

 Mucinous

0.805

0.328-1.977

Perineural invasion

 Negative

1 (reference)

1 (reference)

 Positive

2.002

1.276–3.144

1.646

1.018–2.660

Vascular invasion

 Negative

1 (reference)

1 (reference)

 Positive

1.841

1.261–2.690

0.911

0.589–1.410

Adjuvant CT

 No

1 (reference)

1 (reference)

 Yes

1.950

1.524–2.495

1.289

0.851–1.953

MS status/MMR status

NI

 MSS/MMR-proficient

1 (reference)

 MSI/MMR-deficient

1.060

0.711–1.581