Fig. 1
From: Iron-dependent cell death as executioner of cancer stem cells
Schematic model of iron-dependent cell death. Salinomycin or ironomycin was physically accumulated by lysosomes of CSCs, as a result of iron overload followed by an iron-catalysed lysosomal production of ROS and lipid hydroperoxides via Fenton reaction, subsequent driven DNA damage and cell death that known as ferroptosis. Fenton reaction describes the redox reaction of iron (Fe2+) with different peroxide species to generate hydroxyl (•OH) or alkoxyl (RO•) radicals. Ferric iron (Fe3+) can be recycled to Fe2+ by superoxide (•O2−) generating molecular oxygen (O2). The proposed mechanism was drawn by Bin Zhao and Xin Li based on Mai′ paper [8]