Fig. 1

Strategy for the detection of imbalanced expression of the ALK fusion gene 5′/3′ portion. a shows ALK and the partners’ genomic DNA structures and breakpoint locations. b shows the ALK fusion gene in which the 3′ portion of the ALK gene (right) is fused with the 5′ portion of the partners (left). c shows the normal mRNA structure of the ALK gene (right) and the partners (left). The a or b expression level represents the ALK gene (a = b). d shows the ALK fusion gene mRNA structure, in which the 3′ portion of the ALK gene (right) is fused with the 5′ portion of the partners (left). The c expression level represents the ALK fusion gene