Fig. 8
The Schematic diagram of GDF15 activating the PI3K/AKT and MAPK pathway in cervical cancer progression. GDF15 promotes cell proliferation and tumor formation in cervical cancer by which GDF15 forms a protein complex with ErbB2 and activates PI3K/AKT and MAPK pathways and reveals the mechanism about the change of cell cycle associated molecules such as p21, CDK4/CyclinD1, CDK2/CylinE1