Fig. 1

VEGF signaling inhibition increased tumor metastasis and MET activation. a Inhibitory effects of vehicle and VEGF antibody on HCC growth and intrahepatic metastasis in the hepa1-6 orthotopic models. Tumor volumes and numbers of tumor foci in the orthotopic implantation models were measured and quantified. b-e The effects of vehicle and VEGF antibody on EMT markers, tumor vascularity (CD34), hypoxia (HIF-1α), MET and P-MET expression detected by IHC and Western blot. Data are shown as the mean ± SD. Significant differences were determined using Student’s t test. *: P < 0.05; **: P < 0.01; NS: No Significance