Fig. 2

The cell proliferation assay demonstrating the cell viability of the AGS (a) and MKN45 (b) cell lines, expressed as a percentage of control group by the CCK-8 assay. AGS (c) and MKN45 (d) cell lines were treated with APG-115 (0.02 mol/L and 0.2 mol/L) and/or radiation (4Gy) for 0 to 48 h. Relative expression of MDM2, p21, PUMA and BAX mRNA compared with the control at 0 h was determined by RT-qPCR