Fig. 5

Chibby inhibits Wnt/β-catenin signaling-induced PDK1 expression and aerobic glycolysis in NPC cells. a Western blotting analysis of PDK1 in β-catenin-overexpressed CNE1 and HK-1 cells after Chibby overexpression. b Cellular glucose uptake and lactate release levels were measured in β-catenin-overexpressed CNE1 and HK-1 cells following knockdown of PDK1. c Cellular glucose uptake, d Lactate levels were measured in CNE1 and HK-1 cells following overexpression of β-catenin, Chibby, PDK1, alone or in combination. Data were expressed as the mean ± SD, n = 3 for each group. *, p < 0.05; **, p < 0.001