Fig. 8
From: The oncogenic neurotrophin receptor tropomyosin-related kinase variant, TrkAIII
TrkAIII sensitizes NB cells to TRAIL-induced apoptosis. Schematic representation of: a) cFLIP and Bcl-2 protein family inhibitors of the extrinsic and intrinsic apoptosis pathways in NB cells. b) One-way pro-apoptotic crosstalk between the TRAIL activated TRAIL receptor pathway and TrkAIII pathways, resulting from TRAIL-induced, Shp-dependent c-Src activation, Shp-1/cSrc/TrkAIII complexing, Shp-1-dependent TrkAIII de-phosphorylation, resulting in (c) TrkAIII/cFLIP complexing that alters the caspase 8/cFLIP ratio at death receptors, inducing delayed apoptosis through the extrinsic pathway