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Fig. 3 | Journal of Experimental & Clinical Cancer Research

Fig. 3

From: Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint

Fig. 3

WEE1/PLK1 blockade induces HR deficiency in GC cells. a MKN45 and AGS cells were subjected to 0.3 μM AZD1775 with/without 20 μM olaparib for 48 h and protein extracts were probed with indicated antibodies for immunoblots. b and c Upon treatment of WEE1/PLK1 knockdown by siRNA, immunoblots were performed for WEE1, PLK1 and indicated HR-related proteins. AZD, AZD1775; Ola, olaparib; Com, Combination

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