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Table 1 Current Clinical Trials (as of April 2018)

From: The expansion of targetable biomarkers for CAR T cell therapy

Target Name Function Disease Clinical Trials in 2018
CD19 Cluster of Differentiation 19 Dominant signaling component on mature B cells ALL, B cell lymphoma, leukemia, Non-Hodgkin lymphoma, NCT03366350b, NCT03366324b, NCT02546739b, NCT03448393b, NCT03467256b, NCT03488160b, NCT03016377b, NCT03468153b, NCT03483688b, NCT03398967b, NCT03229876b, NCT03455972b, NCT03423706b, NCT03497533b
Mesothelin   exact function of mesothelin in these normal mesothelial cells is unclear. Pancreatic cancer, Cervical Cancer, Ovarian Cancer, Lung Cancer, Peritoneal carcinoma, Fallopian tube cancer, Colorectal Cancer, Breast Cancer NCT02930993a, NCT03182803a, NCT03030001a, NCT02706782a, NCT01583686a, NCT03356795a, NCT03054298a, NCT03267173a, NCT02792114a, NCT02959151a, NCT02580747a, NCT02414269a, NCT02465983a, NCT03323944a,
Her2 Human Epidermal Growth Factor Receptor 2 Activate intracellular signaling pathways in response to extracellular signals. CNS tumor, Breast Cancer, Ovarian Cancer, Lung Cancer, Gastric Cancer, Colorectal Cancer, Glioma, Pancreatic Cancer, Glioblastoma NCT03500991b, NCT03423992b, NCT02713984a, NCT03267173a, NCT02792114a, NCT02442297a, NCT00889954a, NCT03423992a, NCT01109095a, NCT02706392a, NCT00902044a, NCT03389230a,
NCT01818323a
PSCA Prostate Stem Cell Antigen Not well understood Pancreatic cancer, lung cancer CT03198052a, NCT02744287a, NCT03267173a
CEA Carcinoembryonic antigen Cell adhesion Liver metastases, lung cancer, colorectal cancer, gastric cancer, breast cancer, pancreatic cancer, NCT02850536a, NCT02349724a, NCT03267173a, NCT02959151, NCT01212887a
CD33 Siglec-3 Transmembrane receptor on myeloid lineage Myeloid leukemia, NCT03473457b, NCT02958397a, NCT03126864a, NCT03222674a,
GAP GTPase-activating protein Terminating G protein signaling Solid tumors NCT02932956b
GD2 Ganglioside G2   Glioma, Cervical cancer, sarcoma, neuroblastoma, NCT03423992b, NCT03356795a, NCT02992210a, NCT01953900a, NCT02761915, NCT03373097a, NCT02765243a, NCT03423992a, NCT03294954a, NCT03356782a, NCT02919046a,
CD5 Cluster of differentiation 5 TCR inhibitory molecule T cell acute lymphoblastic lymphoma, T-non-Hodgkin lymphoma, NCT03081910a,
PSMA (PSMA/TGFβ) Prostate specific membrane antigen Transmembrane protein Cervical cancer, Prostate cancer, Bladder cancer NCT03356795a, NCT03089203a (-TGFβ), NCT03185468a, NCT01140373a
ROR1 Receptor Tyrosine Kinase like Orphan Receptor 1 Modulates neurite growth in the CNS Breast cancer, lung cancer, lymphoblastic leukemia, NCT02706392a,
CD123 IL-3RA Involved in hematopoietic progenitor cell differentiation and proliferation AML, Leukemia, NCT03473457b, NCT03125577a, NCT02937103a, NCT03114670a, NCT02159495a, NCT03098355a, NCT03222674a, NCT03203369a, NCT03190278a,
CD70 Cluster of differentiation 70 Induces proliferation of costimulated T cells B cell malignancies, pancreatic cancer, renal cell cancer, breast cancer, melanoma, ovarian cancer NCT03125577a, NCT02830724a,
CD38 Cluster of differentiation 38 Cell adhesion, signal transduction, and calcium signaling Myeloma, NCT03464916b, NCT03473496b, NCT03473457b, NCT03125577a, NCT03222674a, NCT03271632a,
BCMA B cell maturation antigen Mediates the survival of plasma cells Myeloma NCT03448978b, NCT03473496b, NCT03430011b, NCT03455972b, NCT02954445a, NCT03322735a, NCT03338972a, NCT03318861a, NCT02215967a, NCT03093168a, NCT03274219a, NCT03302403a, NCT03492268a, NCT03288493a, NCT03070327a, NCT03196414a, NCT03448978a, NCT02958410a, NCT03287804a, NCT03473496a, NCT03380039a, NCT03430011a, NCT03361748a, NCT03455972a, NCT02546167a, NCT03271632a
Muc1 Mucin 1 Mucous barrier formation on epithelial surfaces Sarcoma, Leukemia, Pancreatic cancer, cervical cancer, lung cancer, hepatocellular carcinoma, breast cancer, glioma, colorectal cancer, gastric cancer NCT03179007a, NCT02587689a, NCT02617134a, NCT03198052a, NCT03356795a, NCT03267173a, NCT03222674a, NCT03356782a
EphA2 Ephrin type-A receptor 2 precursor Eph-ephrin bidirectional signaling pathway of mammalian cells Glioma NCT03423992b
EGFRVIII Epidermal growth factor receptor variant III Cell differentiation and proliferation Glioblastoma NCT03283631b
IL13Ra2 Interleukin 13 receptor, alpha 2 Signal processing via Jak-STAT Glioma NCT02208362a
CD133 Prominin-1 unknown Glioma, AML, Liver Cancer, Pancreatic Cancer, Ovarian Tumor, Colorectal Cancer, Breast Cancer NCT03473457b, NCT03356782a, NCT03423992b
GPC3 Glypican 3 Regulate cell growth, division, and survival Heptocellular carcinoma, lung cancer, Lymphoma, Leukemia, Pancreatic Cancer, Colorectal Cancer NCT02905188b, NCT02932956b, NCT02715362a, NCT03130712a, NCT02395250a, NCT02876978a, NCT03198546a, NCT02723942a, NCT03084380a, NCT03302403a, NCT03146234a, NCT02959151a,
EpCam Epithelial cell adhesion molecule precursor Embryonic stem cell proliferation and differentiation Breast Cancer, Colon Cancer, Pancreatic Cancer, Esophageal Carcinoma, Gastric Cancer, Prostate Cancer, Hepatic Carcinoma, Lymphoma, Leukemia NCT02915445a, NCT03013712a, NCT02729493a, NCT02725125a, NCT02728882a, NCT02735291a
FAP Fibroblast activation protein alpha Neuropeptide regulation. hFGF21 inactivation Pleural Mesothelioma NCT01722149a
  1. Note. a; indicate trials ongoing/active, b; indicate trials that started in 2018