Table 1 Current Clinical Trials (as of April 2018)

CD19

Cluster of Differentiation 19

Dominant signaling component on mature B cells

ALL, B cell lymphoma, leukemia, Non-Hodgkin lymphoma,

NCT03366350^b, NCT03366324^b, NCT02546739^b, NCT03448393^b, NCT03467256^b, NCT03488160^b, NCT03016377^b, NCT03468153^b, NCT03483688^b, NCT03398967^b, NCT03229876^b, NCT03455972^b, NCT03423706^b, NCT03497533^b

Mesothelin

exact function of mesothelin in these normal mesothelial cells is unclear.

Pancreatic cancer, Cervical Cancer, Ovarian Cancer, Lung Cancer, Peritoneal carcinoma, Fallopian tube cancer, Colorectal Cancer, Breast Cancer

NCT02930993^a, NCT03182803^a, NCT03030001^a, NCT02706782^a, NCT01583686^a, NCT03356795^a, NCT03054298^a, NCT03267173^a, NCT02792114^a, NCT02959151^a, NCT02580747^a, NCT02414269^a, NCT02465983^a, NCT03323944^a,

Her2

Human Epidermal Growth Factor Receptor 2

Activate intracellular signaling pathways in response to extracellular signals.

CNS tumor, Breast Cancer, Ovarian Cancer, Lung Cancer, Gastric Cancer, Colorectal Cancer, Glioma, Pancreatic Cancer, Glioblastoma

NCT03500991^b, NCT03423992^b, NCT02713984^a, NCT03267173^a, NCT02792114^a, NCT02442297^a, NCT00889954^a, NCT03423992^a, NCT01109095^a, NCT02706392^a, NCT00902044^a, NCT03389230^a,

NCT01818323^a

PSCA

Prostate Stem Cell Antigen

Not well understood

Pancreatic cancer, lung cancer

CT03198052^a, NCT02744287^a, NCT03267173^a

CEA

Carcinoembryonic antigen

Cell adhesion

Liver metastases, lung cancer, colorectal cancer, gastric cancer, breast cancer, pancreatic cancer,

NCT02850536^a, NCT02349724^a, NCT03267173^a, NCT02959151_, NCT01212887^a

CD33

Siglec-3

Transmembrane receptor on myeloid lineage

Myeloid leukemia,

NCT03473457^b, NCT02958397^a, NCT03126864^a, NCT03222674^a,

GAP

GTPase-activating protein

Terminating G protein signaling

Solid tumors

NCT02932956^b

GD2

Ganglioside G2

Glioma, Cervical cancer, sarcoma, neuroblastoma,

NCT03423992^b, NCT03356795^a, NCT02992210^a, NCT01953900^a, NCT02761915, NCT03373097^a, NCT02765243^a, NCT03423992^a, NCT03294954^a, NCT03356782^a, NCT02919046^a,

CD5

Cluster of differentiation 5

TCR inhibitory molecule

T cell acute lymphoblastic lymphoma, T-non-Hodgkin lymphoma,

NCT03081910^a,

PSMA (PSMA/TGFβ)

Prostate specific membrane antigen

Transmembrane protein

Cervical cancer, Prostate cancer, Bladder cancer

NCT03356795^a, NCT03089203^a (-TGFβ), NCT03185468^a, NCT01140373^a

ROR1

Receptor Tyrosine Kinase like Orphan Receptor 1

Modulates neurite growth in the CNS

Breast cancer, lung cancer, lymphoblastic leukemia,

NCT02706392^a,

CD123

IL-3RA

Involved in hematopoietic progenitor cell differentiation and proliferation

AML, Leukemia,

NCT03473457^b, NCT03125577^a, NCT02937103^a, NCT03114670^a, NCT02159495^a, NCT03098355^a, NCT03222674^a, NCT03203369^a, NCT03190278^a,

CD70

Cluster of differentiation 70

Induces proliferation of costimulated T cells

B cell malignancies, pancreatic cancer, renal cell cancer, breast cancer, melanoma, ovarian cancer

NCT03125577^a, NCT02830724^a,

CD38

Cluster of differentiation 38

Cell adhesion, signal transduction, and calcium signaling

Myeloma,

NCT03464916^b, NCT03473496^b, NCT03473457^b, NCT03125577^a, NCT03222674^a, NCT03271632^a,

BCMA

B cell maturation antigen

Mediates the survival of plasma cells

Myeloma

NCT03448978^b, NCT03473496^b, NCT03430011^b, NCT03455972^b, NCT02954445^a, NCT03322735^a, NCT03338972^a, NCT03318861^a, NCT02215967^a, NCT03093168^a, NCT03274219^a, NCT03302403^a, NCT03492268^a, NCT03288493^a, NCT03070327^a, NCT03196414^a, NCT03448978^a, NCT02958410^a, NCT03287804^a, NCT03473496^a, NCT03380039^a, NCT03430011^a, NCT03361748^a, NCT03455972^a, NCT02546167^a, NCT03271632^a

Muc1

Mucin 1

Mucous barrier formation on epithelial surfaces

Sarcoma, Leukemia, Pancreatic cancer, cervical cancer, lung cancer, hepatocellular carcinoma, breast cancer, glioma, colorectal cancer, gastric cancer

NCT03179007^a, NCT02587689^a, NCT02617134^a, NCT03198052^a, NCT03356795^a, NCT03267173^a, NCT03222674^a, NCT03356782^a

EphA2

Ephrin type-A receptor 2 precursor

Eph-ephrin bidirectional signaling pathway of mammalian cells

Glioma

NCT03423992^b

EGFRVIII

Epidermal growth factor receptor variant III

Cell differentiation and proliferation

Glioblastoma

NCT03283631^b

IL13Ra2

Interleukin 13 receptor, alpha 2

Signal processing via Jak-STAT

Glioma

NCT02208362^a

CD133

Prominin-1

unknown

Glioma, AML, Liver Cancer, Pancreatic Cancer, Ovarian Tumor, Colorectal Cancer, Breast Cancer

NCT03473457^b, NCT03356782^a, NCT03423992^b

GPC3

Glypican 3

Regulate cell growth, division, and survival

Heptocellular carcinoma, lung cancer, Lymphoma, Leukemia, Pancreatic Cancer, Colorectal Cancer

NCT02905188^b, NCT02932956^b, NCT02715362^a, NCT03130712^a, NCT02395250^a, NCT02876978^a, NCT03198546^a, NCT02723942^a, NCT03084380^a, NCT03302403^a, NCT03146234^a, NCT02959151^a,

EpCam

Epithelial cell adhesion molecule precursor

Embryonic stem cell proliferation and differentiation

Breast Cancer, Colon Cancer, Pancreatic Cancer, Esophageal Carcinoma, Gastric Cancer, Prostate Cancer, Hepatic Carcinoma, Lymphoma, Leukemia

NCT02915445^a, NCT03013712^a, NCT02729493^a, NCT02725125^a, NCT02728882^a, NCT02735291^a

FAP

Fibroblast activation protein alpha

Neuropeptide regulation. hFGF21 inactivation

Pleural Mesothelioma

NCT01722149^a