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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: High expression of Ras-related protein 1A promotes an aggressive phenotype in colorectal cancer via PTEN/FOXO3/CCND1 pathway

Fig. 5

RAP1A promotes CRC growth through regulating PTEN/FOXO3/ CCND1 signaling pathway. a: The heat map depicts significantly expressed genes affected by RAP1A knockdown. b: Canonical pathway analysis indicates the top ten pathways enriched of significantly expressed genes. c: Disease and function analysis indicates the top ten biological functions enriched of significantly expressed genes. d: the mRNA expression of PTEN and FOXO3 gene is increased while that of CCND1 gene is decreased in knockdown (KD) group as compared with negative control (NC) group in SW620 cells. e: the protein expression of PTEN and FOXO3 is increased while that of CCND1 is decreased in KD group as compared with NC group in SW620 and HT-29 cells. ** means p < 0.01

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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