Fig. 5

STAT3 elevated LINC01287 expression via c-jun. a The putative transcription factor-binding sites of c-jun in the LINC01287 promoter region. b Western blot revealed that STAT3 positively regulated c-jun expression. c Knockdown of c-jun decreased the expression of miR-298 in both Huh7 and Bel7402 cells. d An up-regulation of wild-type miR-298 promoter luciferase activity was observed upon up-regulation of c-jun in Huh cells. e When c-jun binding sites on LINC01287 were mutated, the effect of c-jun on LINC01287 in Huh7 cells was abolished. f In si-STAT3 cells, the forced overexpression of c-jun increased LINC01287 expression. g In HCC cells in which STAT3 was overexpressed, the knockdown of c-jun decreased LINC01287 expression. h LINC01287 expression was positively correlated with STAT3 expression in HCC