Fig. 6
From: PCBP1 depletion promotes tumorigenesis through attenuation of p27Kip1 mRNA stability and translation
Relevance of PCBP1 to p27 expression in human cancer samples. (a) Representative IHC staining of PCBP1 and p27 protein expression in tumor adjacent normal and tumor regions of ovary carcinoma. Scale bars are equal to 50 μm. (b) Statistical analysis of PCBP1 and p27 in normal and malignant tissues of ovary. 18 normal tissues and 21 carcinoma tissues were analyzed. The unpaired student t test was used to check the group difference. p values are shown. (c) Representative IHC staining of PCBP1 and p27 protein expression in the paired adjacent normal and tumor regions of colon carcinoma. Scale bars are equal to 50 μm. (d) Statistical analysis of PCBP1 and p27 expression in 10 paired fresh normal and malignant tissues of colon tissues. The paired student t test was carried out to check the group difference. p values are shown. (e) Representative IHC staining of p27 ubiquitin ligase, Skp2 protein expression in tumor adjacent normal and tumor regions of colon carcinoma. No evident Skp2 expression difference was observed. Scale bars are equal to 50 μm