Skip to main content

Table 2 Most significantly enriched GO categories (adjP ≤10−5) within the differentially Curcu-regulated proteins datasets

From: SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

GO term

# of proteins in the dataset (a)

# of proteins in the background dataset (b)

% of proteins

Fold enrichment

AdjP-Value (BH method)

Cellular Component (CC)

 Enriched in Curcu-Down-Regulated protein dataset

  Cytoplasm

204

5684

87.55

2.96

9.19E-75

  Exosomes

153

2043

65.67

6.18

7.35E-89

  Nucleus

145

5847

62.23

2.05

7.44E-22

  Lysosome

110

1620

47.21

5.

8.46E-54

  Centrosome

96

656

41.20

12.08

1.64E-76

  Cytosol

82

1178

35.19

5.75

1.28E-38

  Nucleolus

62

1257

26.61

4.07

3.99E-2

  Mitochondrion

59

1259

25.32

3.87

5.61E-18

  Cytoskeleton

30

427

12.88

5.8

6.42E-13

  Proteasome complex

18

34

7.73

43.7

3.95E-24

  Microtubule

12

129

5.15

7.68

3.70E-06

  Proteasome regulatory particle

5

8

2.15

51.62

9.69E-07

 Enriched in Curcu-Up Regulated protein dataset

  

  Mitochondrion

65

1259

45.77

6.99

1.91E-17

  Lysosome

51

1620

35.92

4.26

3.69E-06

  Endoplasmic reticulum

27

1104

19.01

3.31

2.89E-05

  Mitochondrial respiratory chain complex I

13

46

9.15

38.29

2.39E-15

  Mitochondrial membrane

9

56

6.34

21.78

3.73E-08

  Mitochondrial inner membrane

7

58

4.93

16.36

2.22E-05

  Mitochondrial respiratory chain

6

8

4.23

101.6

7.90E-10

  Mitochondrial outer membrane translocase complex

5

6

3.52

112.88

1.91E-08

Molecular Function (MF)

 Enriched in Curcu-Down-Regulated protein dataset

  Ubiquitin-specific protease activity

26

377

11.16

5.69

9.80E-11

  Chaperone activity

17

126

7.30

11.14

4.68E-11

  Translation regulator activity

11

101

4.72

9

2.97E-06

  Isomerase activity

7

45

3

12.85

6.02E-05

 Enriched in Curcu-Up Regulated protein dataset

  Oxidoreductase activity

12

161

8.45

10.1

5.99E-07

Biological Process (BP)

 Enriched in Curcu-Down Regulated protein dataset

  Protein metabolism

59

1323

25.32

3.68

1.24E-16

  Metabolism

58

1683

24.89

2.84

9.15E-12

 Enriched in Curcu-Up Regulated protein dataset

  Metabolism

38

1683

26.76

3.06

2.22E-08

  Transport

30

1215

21.13

3.34

2.32E-07

  1. (a) The Curcu-Up-Regulated protein dataset is composed by 233/234 proteins since the protein Q5HYB6_HUMAN (Gene Name: DKFZp686J1372) was not mapped in FunRich database; the Curcu-Up-Regulated protein dataset is composed by 142/143 proteins since the protein CD97_HUMAN (Gene name: CD97) was not mapped in FunRich database; (b) The background dataset (in FunRich database) is composed by 19,230 genes/proteins
Back to article page

Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

Contact us