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Table 2 Most significantly enriched GO categories (adjP ≤10−5) within the differentially Curcu-regulated proteins datasets

From: SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

GO term # of proteins in the dataset (a) # of proteins in the background dataset (b) % of proteins Fold enrichment AdjP-Value (BH method)
Cellular Component (CC)
Enriched in Curcu-Down-Regulated protein dataset
  Cytoplasm 204 5684 87.55 2.96 9.19E-75
  Exosomes 153 2043 65.67 6.18 7.35E-89
  Nucleus 145 5847 62.23 2.05 7.44E-22
  Lysosome 110 1620 47.21 5. 8.46E-54
  Centrosome 96 656 41.20 12.08 1.64E-76
  Cytosol 82 1178 35.19 5.75 1.28E-38
  Nucleolus 62 1257 26.61 4.07 3.99E-2
  Mitochondrion 59 1259 25.32 3.87 5.61E-18
  Cytoskeleton 30 427 12.88 5.8 6.42E-13
  Proteasome complex 18 34 7.73 43.7 3.95E-24
  Microtubule 12 129 5.15 7.68 3.70E-06
  Proteasome regulatory particle 5 8 2.15 51.62 9.69E-07
Enriched in Curcu-Up Regulated protein dataset   
  Mitochondrion 65 1259 45.77 6.99 1.91E-17
  Lysosome 51 1620 35.92 4.26 3.69E-06
  Endoplasmic reticulum 27 1104 19.01 3.31 2.89E-05
  Mitochondrial respiratory chain complex I 13 46 9.15 38.29 2.39E-15
  Mitochondrial membrane 9 56 6.34 21.78 3.73E-08
  Mitochondrial inner membrane 7 58 4.93 16.36 2.22E-05
  Mitochondrial respiratory chain 6 8 4.23 101.6 7.90E-10
  Mitochondrial outer membrane translocase complex 5 6 3.52 112.88 1.91E-08
Molecular Function (MF)
Enriched in Curcu-Down-Regulated protein dataset
  Ubiquitin-specific protease activity 26 377 11.16 5.69 9.80E-11
  Chaperone activity 17 126 7.30 11.14 4.68E-11
  Translation regulator activity 11 101 4.72 9 2.97E-06
  Isomerase activity 7 45 3 12.85 6.02E-05
Enriched in Curcu-Up Regulated protein dataset
  Oxidoreductase activity 12 161 8.45 10.1 5.99E-07
Biological Process (BP)
Enriched in Curcu-Down Regulated protein dataset
  Protein metabolism 59 1323 25.32 3.68 1.24E-16
  Metabolism 58 1683 24.89 2.84 9.15E-12
Enriched in Curcu-Up Regulated protein dataset
  Metabolism 38 1683 26.76 3.06 2.22E-08
  Transport 30 1215 21.13 3.34 2.32E-07
  1. (a) The Curcu-Up-Regulated protein dataset is composed by 233/234 proteins since the protein Q5HYB6_HUMAN (Gene Name: DKFZp686J1372) was not mapped in FunRich database; the Curcu-Up-Regulated protein dataset is composed by 142/143 proteins since the protein CD97_HUMAN (Gene name: CD97) was not mapped in FunRich database; (b) The background dataset (in FunRich database) is composed by 19,230 genes/proteins