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Table 3 Biological Pathway enrichment analysis of “metabolic” proteins down-regulated and up-regulated by curcumin

From: SWATH-MS based quantitative proteomics analysis reveals that curcumin alters the metabolic enzyme profile of CML cells by affecting the activity of miR-22/IPO7/HIF-1α axis

Biological pathway % of proteins AdjP-Value (BH method) Proteins
Curcu-Down-Regulated “metabolic” proteins
 Metabolism 29.82 2.04E-07 TALDO1; ARG2; GSTP1; AHCY; TXN; FASN; TKT; COX6B1; GMPS; PAICS; HPRT1; CAD; ATIC; GSTO1; ACLY; GOT1; TK1;
 Metabolism of carbohydrates 14.04 2.04E-07 TPI1; TALDO1; GPI; MDH1; PGK1; TKT; PGD; GOT1;
 Gluconeogenesis 8.77 1.19E-06 TPI1; GPI; MDH1; PGK1; GOT1;
 Glucose metabolism 8.77 1.60E-05 TPI1; GPI; MDH1; PGK1; GOT1;
 Glycolysis 5.26 5.13E-05 TPI1; GPI; PGK1;
 Cytosolic tRNA aminoacylation 7.02 1.07E-04 DARS; PPA1; VARS; YARS;
 HIF-1-alpha transcription factor network 7.02 4.28E-03 ALDOA; PKM; LDHA; PGK1;
 Pentose phosphate pathway (oxidative branch) 3.51 4.78E-03 G6PD; PGD;
Curcu-Up-Regulated “metabolic” proteins
 Respiratory electron transport 40.5 3.0E-24 UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NDUFB6; NDUFB5; NDUFB3; NDUFB9;
 The citric acid (TCA) cycle and respiratory electron transport 43.2 1.4E-23 UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NNT; NDUFB6; NDUFB5; NDUFB3; NDUFB9;
 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. 40.5 1.9E-23 UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NDUFB6; NDUFB5; NDUFB3; NDUFB9;
 Metabolism 45.9 1.4E-11 UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; CYP51A1; UQCRH; NDUFA9; UQCRB; MT-ND5; NNT; NDUFB6; NDUFB5; NDUFB3; NDUFB9;
 Cholesterol biosynthesis 8.1 1.5E-03 FDFT1; CYP51A1; DHCR24;