Table 3 Biological Pathway enrichment analysis of “metabolic” proteins down-regulated and up-regulated by curcumin

 Metabolism

29.82

2.04E-07

TALDO1; ARG2; GSTP1; AHCY; TXN; FASN; TKT; COX6B1; GMPS; PAICS; HPRT1; CAD; ATIC; GSTO1; ACLY; GOT1; TK1;

 Metabolism of carbohydrates

14.04

2.04E-07

TPI1; TALDO1; GPI; MDH1; PGK1; TKT; PGD; GOT1;

 Gluconeogenesis

8.77

1.19E-06

TPI1; GPI; MDH1; PGK1; GOT1;

 Glucose metabolism

8.77

1.60E-05

TPI1; GPI; MDH1; PGK1; GOT1;

 Glycolysis

5.26

5.13E-05

TPI1; GPI; PGK1;

 Cytosolic tRNA aminoacylation

7.02

1.07E-04

DARS; PPA1; VARS; YARS;

 HIF-1-alpha transcription factor network

7.02

4.28E-03

ALDOA; PKM; LDHA; PGK1;

 Pentose phosphate pathway (oxidative branch)

3.51

4.78E-03

G6PD; PGD;

 Respiratory electron transport

40.5

3.0E-24

UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NDUFB6; NDUFB5; NDUFB3; NDUFB9;

 The citric acid (TCA) cycle and respiratory electron transport

43.2

1.4E-23

UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NNT; NDUFB6; NDUFB5; NDUFB3; NDUFB9;

 Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

40.5

1.9E-23

UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; UQCRH; NDUFA9; UQCRB; MT-ND5; NDUFB6; NDUFB5; NDUFB3; NDUFB9;

 Metabolism

45.9

1.4E-11

UQCRC1; CYC1; COX5B; NDUFS1; NDUFA5; NDUFB4; NDUFV1; CYP51A1; UQCRH; NDUFA9; UQCRB; MT-ND5; NNT; NDUFB6; NDUFB5; NDUFB3; NDUFB9;

 Cholesterol biosynthesis

8.1

1.5E-03

FDFT1; CYP51A1; DHCR24;