Fig. 5

Exosome mediated transfer of lncRNA PART1 induces gefitinib resistance. a Intercellular trafficking of exosomes among different cell lines by isolated exosomes labeled with PKH26 dye. b RT-qPCR analysis of exosomal lncRNA PART1 expression level in cells treated with extracted exosomes or blank control for 48 h. ^**P < 0.01 compared to PBS control c CCK8 assay was used for the detection of cell viability in the two cell lines after treatment with extracted exosomes or blank control for 48 h. ^*P < 0.05 compared to PBS control d Knockdown of lncRNA PART1 abrogated the effect induced by exosome treatment as evidenced by CCK8 assay. ^*P < 0.05 compared to si-NC + Exosome group