Fig. 6

RBM38 suppressed tumor growth in nude mice. a The growth of HepG2-RBM38-OE and control cells orthotopically injected into mammary fat pads of the nude mice and the growth of tumors was followed up over 6 weeks. b RBM38 over expressed HepG2-RBM38-OE cells formed smaller (p = 0.032) and lighter (p = 0.038) tumor compared to the control cells (NC). Data were mean values of experiments mean ± SEM. c TUNEL (green) in the penumbra area at 72 h post MCAO showing a significant decrease in the number of TUNEL-positive cells in the HepG2-RBM38-OE cells compared to the corresponding controls (p = 0.034361). Representative photographs and quantification are shown. Magnification 200×. d Immunohistochemical staining showing that tumors originating from HepG2-RBM38-OE cells had increased WTP53 and decreased mdm2 and ki67 levels compared to those originating from control cells, original magnification, × 200