Fig. 4

Clinical relevance of RIF1 and hTERT in EOC. a GSEA plot showing that RIF1 expression was positively correlated with TERT-activated gene signatures and TERT downstream PI3K/AKT signaling in the GEO data set (NCBI/GEO/GSE7463; n = 43). b Bioinformatics analysis based on TCGA database showed the mRNA expression levels of RIF1 positively correlated with hTERT expression level in ovarian cancer tissues. c and d Immunohistochemical staining suggesting that RIF1 expression correlated positively with hTERT expression in 75 clinical EOC specimens. Percentage of EOC specimens showing low or high RIF1 expression relative to the expression levels of hTERT. ** P < 0.01. e The relative expression of RIF1 and hTERT was used to perform the correlation analysis