Fig. 7

Clinical pathological analysis. a Representative section images of PAR1, Twist1, VEGFR1, VEGFR2, E-cadherin, vimentin, MMP-2 and MMP-9 in tissues where PAR1 was overexpressed and underexpressed (PAR1, Twist1, VEGFR1, VEGFR2, E-cadherin, or vimentin, MMP-2 and MMP-9) shown in brown; cell nucleus shown in blue). b The expression levels of Twist1, VEGFR1, VEGFR2, E-cadherin, vimentin, and PAR1 in human HCC tissues were scored by staining index and pearson correlation analysis was then performed. A positive correlation exists between PAR1, Twist1, VEGFR1, VEGFR2, vimentin, MMP-2 and MMP-9. A negative correlation exists between PAR1 and E-cadherin (P < 0.05). c Survival data of clinical cases. Survival rate of tumor patients was significantly decreased under high expression levels of both PAR1 and Twist1