Fig. 3

Downregulation of TIPE3 is associated with its CGI hypermethylation. a Relative mRNA level of TIPE3 in NPEC tissues (n = 13) and NPC (n = 17); b Relative mRNA level of TIPE3 in NPEC tissues (n = 18) and NPC (n = 18) from published microarray data (GSE53819); c Relative mRNA levels of TIPE3 in NPC and NPEC cell lines; d-e Relative methylation (d) and mRNA (e) levels of TIPE3 in NPC and NPEC cell lines treated with or without DAC; f TIPE3 mRNA level detected in cancers from TCGA database; T: tumor; N: normal; g The correlation between the TIPE3 (cg05905176) methylation level and mRNA level in cancers from TCGA database. Mean ± SD; *, P < 0.01, Student’s t-test