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Table 1 Regulation of PTEN expression by miRNAs

From: Regulation of PTEN expression by noncoding RNAs

MiRNA PTEN expression Mechanism Disease Reference
miR-21 Down directly targeting PTEN mRNA Gastric cancer, HNSCC, CCRCC [52,53,54]
miR-130 Down directly targeting PTEN mRNA Bladder cancer, Breast invasive carcinoma, HCAECs injury, Inflammatory responses, PD, Lung adenocarcinoma, Colon adenocarcinoma [55,56,57,58]
miR-130 Up directly targeting PTEN mRNA NSCLC [59]
miR-451 Up directly targeting PTEN mRNA Lung cancer, Ovarian cancer [60, 61]
miR-221 /222 Down directly targeting PTEN mRNA NSCLC,HCC, TRAIL-induced cell death [62]
miR-301a Down directly targeting PTEN mRNA Breast cancer, Neuronal death, Ewing’s carcoma, Melanoma, Insulin resistance [63,64,65,66,67]
miR-214 Down directly targeting PTEN mRNA Tumorigenesis, Immunology, Cardiac injury [68,69,70,71]
miR-494 Down directly targeting PTEN mRNA Ischemia/Reperfusion -induced myocardial injury [72, 73]
miR-155-5p/130b/616/19/92a/10a/106a/429/26a /486-5p Down directly targeting PTEN mRNA HCC, NSCLC, Breast cancer, Lung cancer, Colorectal Cancer, Chronic myeloid leukemia, Intestinal cancer, Acute T-cell lymphoblastic leukemia [74,75,76,77,78,79,80,81,82,83,84]
miR-29 Up inducing the hypomethylation of PTEN promoter by inhibiting DNMT1, DNMT3b and SET1A expression Liver fibrosis [87, 88]
miR-101 Up inducing the hypomethylation of PTEN promoter by inhibiting DNMT3A expression Lung cancer [89, 90]
miR-185 Up inducing the hypomethylation of PTEN promoter by inhibiting DNMT1 expression HCC [91]