MiRNA | PTEN expression | Mechanism | Disease | Reference |
---|---|---|---|---|
miR-21 | Down | directly targeting PTEN mRNA | Gastric cancer, HNSCC, CCRCC | |
miR-130 | Down | directly targeting PTEN mRNA | Bladder cancer, Breast invasive carcinoma, HCAECs injury, Inflammatory responses, PD, Lung adenocarcinoma, Colon adenocarcinoma | |
miR-130 | Up | directly targeting PTEN mRNA | NSCLC | [59] |
miR-451 | Up | directly targeting PTEN mRNA | Lung cancer, Ovarian cancer | |
miR-221 /222 | Down | directly targeting PTEN mRNA | NSCLC,HCC, TRAIL-induced cell death | [62] |
miR-301a | Down | directly targeting PTEN mRNA | Breast cancer, Neuronal death, Ewing’s carcoma, Melanoma, Insulin resistance | |
miR-214 | Down | directly targeting PTEN mRNA | Tumorigenesis, Immunology, Cardiac injury | |
miR-494 | Down | directly targeting PTEN mRNA | Ischemia/Reperfusion -induced myocardial injury | |
miR-155-5p/130b/616/19/92a/10a/106a/429/26a /486-5p | Down | directly targeting PTEN mRNA | HCC, NSCLC, Breast cancer, Lung cancer, Colorectal Cancer, Chronic myeloid leukemia, Intestinal cancer, Acute T-cell lymphoblastic leukemia | |
miR-29 | Up | inducing the hypomethylation of PTEN promoter by inhibiting DNMT1, DNMT3b and SET1A expression | Liver fibrosis | |
miR-101 | Up | inducing the hypomethylation of PTEN promoter by inhibiting DNMT3A expression | Lung cancer | |
miR-185 | Up | inducing the hypomethylation of PTEN promoter by inhibiting DNMT1 expression | HCC | [91] |