Fig. 6
From: The LAT1 inhibitor JPH203 reduces growth of thyroid carcinoma in a fully immunocompetent mouse model
Tumors of JPH203-treated mice exhibit an increase in TUNEL-positive nuclei and activation of the amino acid stress response. H&E pictures demonstrating PTC/ATC features in (a) a vehicle-treated mouse and PTC features in (b) a JPH203-treated mouse. c, d Ki67-positive cells and BrdU-positive cells were quantified from each mouse and plotted in the graphs. e TUNEL-positive nuclei were quantified from each mouse and plotted in the graph. f, g Atf5, Slc7a8 and Slc3a2 transcription levels were quantified in vehicle- and JPH203-treated animals. Transcription levels of each gene were normalized to Tuba1a and plotted as fold change relative to vehicle level. All statistical analyses were performed by using a two-tailed Mann-Whitney test