Fig. 7

LAT1 is upregulated in human ATC and associated with shorter survival in PTC patients. a SLC7A5 transcription levels were quantified in normal thyroid (n = 10), PTC (n = 14) and ATC (n = 18) samples derived from patients. Transcription levels of each gene were normalized to ACTB and plotted as fold change relative to normal thyroid. Statistical analysis was performed using a Kruskal-Wallis test with Dunn’s correction for multiple comparisons, p-value is indicated. b The PTC dataset (TCGA, Cell 2014) containing 400 tumor samples with RNAseq and survival data was analyzed using the cBioPortal online platform. Z-score > 1 was used to define samples with high SLC7A5 expression (n = 36) and z-score < 1 was used to define samples with low SLC7A5 expression (n = 364). Statistical analysis was performed by using a log-rank test, p-value is indicated. c SLC5A5 expression levels were analyzed in the PTC dataset from (b) and co-occurrence of SLC5A5 downregulation (defined as expression < median) with high SLC7A5 (z-score > 1) was quantified. Statistical analysis was performed by using a one-sided Fisher’s exact test