HSCs-derived COMP drives hepatocellular carcinoma progression by activating MEK/ERK and PI3K/AKT signaling pathways

Table 1 Univariate and multivariate analysis of factors associated with overall survival in hepatocellular carcinoma patients

Features	Univariate Analysis			Multivariate Analysis
Features	HR	95%Cl	P	HR	95%Cl	P
Age (≤50 versus > 50 years)	0.446	0.158–1.370	0.165
Gender (Male versus Female)	2.069	0.612–6.996	0.242
HBV (Negative versus Positive)	0.377	0.103–1.379	0.140
Cirrhosis (Yes versus No)	3.878	1.096–13.721	*0.036*	2.750	0.980–7.716	0.055
AFP (> 400 versus ≤400 ng/mL)	2.235	0.667–7.487	0.192
Vascular Invasion (Yes versus No)	3.524	1.038–11.962	*0.043*	3.408	1.159–10.026	*0.026*
Tumor Size (≤5 versus > 5 cm)	0.120	0.028–0.512	*0.004*	0.333	0.121–0.917	*0.033*
Tumor encapsulation (Complete versus No/incomplete)	0.363	0.121–1.092	0.071
Differentiation (poor versus Well/moderate)	1.307	0.467–3.661	0.611
TNM stage (II/III versus I)	1.546	0.456–5.235	0.484
COMP (high versus low)	13.428	2.844–63.408	*0.001*	6.574	2.154–20.061	*0.001*

HBV hepatitis B virus, AFP alpha-fetoprotein, TNM tumor-node-metastasis, HR hazard ratio, CI confidence interval
Significant values (P<0.05) are in bold italic

ISSN: 1756-9966