Journal of Experimental & Clinical Cancer Research

Table 2 Uni- and multi-variate Cox regression of CLDN7 protein expression for disease free survival (DFS) in 129 ccRCC from Peking University First Hospital (*, p < 0.05. **, p < 0.01)

From: Downregulation of CLDN7 due to promoter hypermethylation is associated with human clear cell renal cell carcinoma progression and poor prognosis

Factors	Univariate analysis		Multivariate analysis
Factors	HR (95% CI)	p	HR (95% CI)	p
CLDN7 Staining Intensity	0.254(0.101–0.639)	0.004**	0.227(0.093–0.551)	0.001**
3 vs. 2 vs. 1 vs. 0	0.254(0.101–0.639)	0.004**	0.227(0.093–0.551)	0.001**
Gender	0.631(0.231–0.722)	0.368
Female vs. Male	0.631(0.231–0.722)	0.368
Age (year)	1.754(0.727–4.233)	0.211	3.600(1.311–9.887)	0.013*
> 55 vs. <=55	1.754(0.727–4.233)	0.211	3.600(1.311–9.887)	0.013*
Laterality	0.906(0.385–2.133)	0.821
Right vs. Left	0.906(0.385–2.133)	0.821
Pathologic T	2.175(1.386–3.413)	0.001**	2.419(1.551–3.773)	< 0.001**
T3 vs. T2 vs. T1	2.175(1.386–3.413)	0.001**	2.419(1.551–3.773)	< 0.001**
Histologic grade	2.938(1.644–5.250)	< 0.001**
G3 vs. G2 vs. G1	2.938(1.644–5.250)	< 0.001**
Creatinine	0.254(0.101–0.639)	0.004**	5.809(2.184–15.454)	< 0.001**
Elevated vs. Normal	0.254(0.101–0.639)	0.004**	5.809(2.184–15.454)	< 0.001**
Urea nitrogen	4.187(1.733–10.113)	0.001**
Elevated vs. Normal	4.187(1.733–10.113)	0.001**

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