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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: Over-expressed lncRNA HOTAIRM1 promotes tumor growth and invasion through up-regulating HOXA1 and sequestering G9a/EZH2/Dnmts away from the HOXA1 gene in glioblastoma multiforme

Fig. 5

HOTAIRM1 decreases histone H3K9me2 and H3K27me3 modifications in the TSS region of the HOXA1 gene in GBM cells. ChIP analysis of a histone H3K9me2 and H3K27me3 modifications; b G9a and EZH2 enrichment in the HOXA1 gene TSS in A172 cells. Knockdown of HOTAIRM1, ChIP analysis of c histone H3K9me2 and H3K27me3 modifications; d G9a and EZH2 enrichment in the HOXA1 gene TSS in A172 cells. ChIP enrichment was measured using qPCR, normalized by the input DNA, Error bars represent the SE of three independent experiments, *P < 0.05

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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