Fig. 5

Prdx3 was identified by LC-MS/MS for CKI against AML, and CKI regulated Prdxs/Trx1 in AML. a Data analysis. b GO annotation with 288 differential expressed proteins. c Heat map showed the changes in 11 functions in 54 differential expressed proteins after CKI treatment. d The interaction between PRDX3 and other selected proteins by STRING. e Validation of Prdx3, Prdx2, and Trx1 protein expression in healthy and AML cells by Western blot. f The protein expression changes to Prdx3, Prdx2, and Trx1 after treatment of AML cells with CKI and their detection by Western blot. g The expression and interaction of Prdx3, Prdx2, and Trx1 after CKI treatment in AML cells and their observation using laser confocal microscopy