Fig. 5

ARS and DHA suppressed CAFs-induced cancer growth and metastasis in vivo. (a) Diagram shows the experimental course of orthotopic model (n = 8). (b-c) Representative images and quantification bioluminescence of breast tumor bearing mice treated with paclitaxel (10 mg/kg), ART (100 mg/kg), ARM (100 mg/kg), ARS (100 mg/kg) and DHA (100 mg/kg). (d) Kaplan-Meier survival curves for breast tumor bearing mice. (e) Probability of metastasis for breast tumor bearing mice. (f) Effect of paclitaxel (10 mg/kg), ART (100 mg/kg), ARM (100 mg/kg), ARS (100 mg/kg) and DHA (100 mg/kg) on tumor growth was investigated in the orthotopic model. (g) H&E stained lungs and livers of mice to confirm the presence of micrometastases. Each experiment was performed at least three times. Data are presented as mean ± SD. *p < 0.05 compared with 4 T1 + L-929 group; **p < 0.01 compared with 4 T1 + L-929 group