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Fig. 6 | Journal of Experimental & Clinical Cancer Research

Fig. 6

From: Helicobacter pylori CagA promotes epithelial mesenchymal transition in gastric carcinogenesis via triggering oncogenic YAP pathway

Fig. 6

a Expression of E-cadherin (an epithelial marker) and N-cadherin (a mesenchymal marker) in AGS cells transfected with YAP cDNA plasmid. b After AGS cells were infected with H. pylori strains 7.13 or PMSS1 and their cagA mutants, Expression of E-cadherin (red) were visualized using Immunofluorescence. c Immunofluorescence was performed for E-cadherin levels. d mRNA levels of YAP downstream genes CTGF, CYR61 and E-cadherin (an epithelial marker) in AGS cells infected with H. pylori strains alone or in combination with VP treatment. e Expression of YAP and mesenchymal markers Slug and N-cadherin in AGS cells treated with CagA+H. pylori PMSS1 or 7.13 alone or in combination with VP. f Expression of YAP, epithelial markers E-cadherin and mesenchymal markers N-cadherin in AGS cells treated with CagA+H. pylori PMSS1 or 7.13 alone or in combination with YAP siRNA. Data for gene expression are mean ± SEM of 3 independent experiments

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