Fig. 7

Activated HSCs promote angiogenesis a, b Immunohistochemistry staining of CD31 staining in subcutaneously implanted tumor under different conditions. c qRT-PCR assay indicated gene expression levels of HSCs treated with exosomes derived from different cells in the presence of miRNA-21 inhibitor or AKT inhibitor. Experiments were performed at least in triplicate. d, e The proliferation of HUVECs with exosomes derived from different cells in the presence of miRNA-21 inhibitor or AKT inhibitor was tested by CCK-8 assay and tube formation assay. Data are mean ± SEM from three independent experiments, *p < 0.05, **p < 0.01, ***p < 0.001 by unpaired Student’s t-test