Fig. 6
From: Dysregulation of miR-6868-5p/FOXM1 circuit contributes to colorectal cancer angiogenesis
Delivery of miR-6868-5p mimic suppresses tumor angiogenesis in vivo. a The nude mice inoculated with HCT116 cells were divided into two treatment groups: control and miR-6868-5p agomir. Tumor size was measured every three days after inoculation. b Xenografted tumors were excised at week 4 post the inoculation, and the tumor weight from different groups was compared. c Representative images of IHC staining for CD31, FOXM1 and IL-8 in indicated agomir-treated tumors. Scale bar = 20 μm. d Representative images of CD31 (red), NG2 (green) and nuclei (blue) immunofluorescence staining in indicated agomir-treated tumors. Higher magnification images are shown in the insets. Scale bar = 50 μm. *p < 0.05, **p < 0.01