Fig. 4

GRINA enhanced the migration and invasion ability of gastric cancer cells. a-b Scratch wound assays revealed that the migration distance was decreased in GRINA siRNA group compared with that in control group after cells were cultured in medium without FBS for 24 h (N = 3). c-d Transwell assay showed that GRINA-depleted cells had less migratory and invasive capacity in BGC-823 and AGS cells (N = 3). e-f Transwell assay showed that GRINA-overexpressed cells had enhanced migratory and invasive capacity in HGC27 and N87 cells (N = 3). Values are mean ± s.d., *P < 0.05, **P < 0.01 (Student’s t-test)