Fig. 7

GRINA knockdown promoted cell apoptosis via Bcl-2 family members. a-b Cell apoptosis assay revealed that apoptosis rates of BGC-823 and AGS cells increased when GRINA was silenced (N = 3). c TUNEL staining reaveled that mice tumor tissues in the GRINA-shRNA group showed higher apoptosis rate than those in the control group (N = 3). d Bcl-2, Bax, Cleaved-caspase3, Cleaved-caspase7, Cleaved-caspase9 were measured by western blotting analysis after GRINA was silenced in BGC-823 and AGS cell lines (N = 3). Values are mean ± s.d., *P < 0.05, ***P < 0.001 (Student’s t-test)