Fig. 6

Co-inoculated macrophages make xenografted pancreatic cancer BxPC-3-luc more resistant to chemotherapy than control. Mice intraperitoneally xenografted with BxPC-3-luc cells were treated with gemcitabine 3 times weekly. Growth curves are shown in the upper panels, and tumor burdens on day 37 are plotted in the lower panels where bars indicate the means and 95% confidence intervals. While chemotherapy significantly suppresses the growth of peritoneal tumors (a), co-inoculation of macrophages offsets the therapeutic effect (b). * p < 0.05 (unpaired t-test)