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Table 2 Cytokines Levels in human melanoma cell lines by Luminex analysis

From: TNF-alpha and metalloproteases as key players in melanoma cells aggressiveness

Cytokines SK-MEL-28 (pg/ml/mgProt) A375 (pg/ml/mgProt) p-Value A375 vs SK-MEL-28
PDGF-bb 5.79 ± 2.5 0.00 ± 0.00 0.0491 down-regulated
IL-1β 5.69 ± 3.59 1.98 ± 1.06 0.0001 down-regulated
IL-9 7228.00 ± 1003.00 1310.91 ± 446.08 0.0121 down-regulated
IP-10 83.44 ± 16.52 2.56 ± 07 0.0011 down-regulated
IL-8 322.20 ± 136.72 64.34 ± 13.87 0.0314 down-regulated
IL-1ra 80.35 ± 4.19 33.93 ± 16.17 0.0086 down-regulated
G-CSF 81.68 ± 14.20 22.94 ± 19.73 0.0138 down-regulated
IL-6 1.06 ± 0.04 5.86 ± 2.33 0.0235 up-regulated
IL-12 4.53 ± 2.59 16.38 ± 1.56 0.0008 up-regulated
Eotaxin 0.07 ± 0.02 54.67 ± 8.47 0.0000 up-regulated
RANTES 10.26 ± 1.62 234.04 ± 80.47 0.0015 up-regulated
IFN-γ 29.91 ± 1.23 348.61 ± 62.18 0.0009 up-regulated
TNF-α 1.09 ± 1.78 23.48 ± 3.46 0.0007 up-regulated
VEGF 2021.13 ± 82.71 2929.27 ± 1180,89 0.0037 up-regulated
  1. Cytokines levels up- and down-regulation expressed in A375 compared to SK-MEL-28