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Fig. 5 | Journal of Experimental & Clinical Cancer Research

Fig. 5

From: SIRT6 drives epithelial-to-mesenchymal transition and metastasis in non-small cell lung cancer via snail-dependent transrepression of KLF4

Fig. 5

KLF4 mediates SIRT6 depletion-induced tumor suppression in vitro. a Western blot analysis of KLF4 protein in A549 and H1299 cells transfected with control or KLF4 siRNA. One representative experiment of three independent experiments are shown. b Transwell invasion assay was used to assess the invasiveness of cells transfected with indicated constructs. Data shown are mean from three independent experiments performed in triplicate. *P < 0.05. c Western blot analysis of KLF4 protein in A549 and H1299 cells transfected with empty vector or KLF4-expressing plasmid. One representative experiment of three independent experiments are shown. d Transwell invasion assay was used to assess the invasiveness of cells transfected with indicated constructs. Data shown are mean from three independent experiments performed in triplicate. *P < 0.05. e Western blot analysis of E-cadherin and vimentin proteins in A549 and H1299 cells transfected with empty vector or KLF4-expressing plasmid after TGF-β1 treatment. One representative experiment of three independent experiments are shown

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