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Fig. 7 | Journal of Experimental & Clinical Cancer Research

Fig. 7

From: Epigenetic reprogramming of epithelial mesenchymal transition in triple negative breast cancer cells with DNA methyltransferase and histone deacetylase inhibitors

Fig. 7

The combination of SGI with MS275 suppresses WNT and mutant p53 pathways, up-regulates H3K27me3. a WB analyses show up-regulation of E-cadherin and full length EpCAM, and down-regulation of TCF4 in TNBC cells. b Immunofluorescence images show presence of EpCAM containing N-terminal EGF domain indicated by staining with EpCAM(VU1D9) antibody in bsMCF-luc cells after the combined treatment. Magnification, 400×. Scale bar, 20 μm. c, d and e WB analyses of mutant p53, ZEB1, EZH2, and H3K27me3. Beta actin and GAPDH were used as loading control

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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