Fig. 2

Toxicity of nintedanib, paclitaxel and the combination in the LM2–4 models. a) Primary tumor model. Different treatments were well tolerated. b) Advanced metastasis model. There were signs of toxicity in mice during the course of treatment (ie. scruffiness, hunched posture), but no significant weight loss. Body weight is considered as a surrogate for toxicity in mice. Data are presented as means ± SD, n = 5 (a) and n = 8–10 (b)