Fig. 6

Nuclear MET mediates stemness and drug resistance. a Nuclear MET expression in PC3 cells upon drug response to doxorubicin (DOX). b Breast cancer MCF7 cells cytotoxicity assay upon treatment with DMSO (control), 60 nM doxorubicin (DOX) alone, antibody (Ab) against MET alone and combined treatment with Dox and antibody against MET. c Nuclear MET induces stem-like cell growth by colony formation assay. d Nuclear MET expression in stem-like cells of C4-2B formed sphere. e C4-2B formed spheres express stem cell markers of SOX2 and OCT4. f-i MET knockdown decreases cancer cell colony formation and membrane MET inhibition by MET antibody (MET Ab) further decreases colony formation