Fig. 3
From: ANKHD1 is required for SMYD3 to promote tumor metastasis in hepatocellular carcinoma
ANKHD1 mediates the pro-migratory and pro-invasive effects of SMYD3. a Migration and invasion assay in stable huh7-SMYD3 cells with ANKHD1 knockdown or not. b Wound healing assay of huh7-SMYD3 cells with ANKHD1 knockdown or not. c In vivo lung metastasis assay was performed using Bel-7402 control, Bel-7402-SMYD3, and Bel-7402-SMYD3 combined with ANKHD1 siRNA or control siRNA injection; representative images of H&E-stained sections were derived from lung metastatic nodules of the four experimental groups; Number of metastatic lung foci observed at the surface of the lungs of mice was counted in each group (n = 6 for each group). Data are presented as mean ± SD for three independent experiments. *P < 0.05