Fig. 1

CXCR4^+/− transgenic mice displayed enhanced AOM/DSS-induced CAC. a The schematic regimen of colitis-associated cancer model by treatment with 3 cycles of AOM/DSS. b Wild type C57BL/6 J mice and CXCR4^+/− mice were treated with AOM/DSS with or without AMD3100 for 63 days. Body weight changes were measured twice a week. c Disease activity index was evaluated in the mice. d Representative images of colons from AOM/DSS-treated WT (n = 8), CXCR4^+/− (n = 8) mice and CXCR4^+/− mice treated with AMD3100 (n = 8). e Colon lengths were measured following treatment. f Average colon polyp counts per mouse were classified by polyp size. g Total polyp counts per mouse were examined in different groups (n = 8). *P < 0.05 vs. WT mice. ^#P < 0.05 vs. CXCR4^+/− mice