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Fig. 9 | Journal of Experimental & Clinical Cancer Research

Fig. 9

From: CXCL12/CXCR4 promotes inflammation-driven colorectal cancer progression through activation of RhoA signaling by sponging miR-133a-3p

Fig. 9

Schematic of proposed molecular model of non-coding RNAs involved in CXCL12/CXCR4-induced CRC invasion and progression. Activation of CXCL12/CXCR4 axis upregulates LncRNA XIST. LncRNA XIST functions as a ceRNA sponging miR-133a-3p, thereby upregulating RhoA, which promoted actin polymerization and actomyosin contractility through the ROCK/p-MLC pathway

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Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966

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