Fig. 7

β-catenin silencing reversed the promotion effects of SPRY2 knockdown on EMT-associated migration and invasion of PDAC cells. a Wound healing assay was carried out to investigate the migratory ability of PANC-1 and SW1990 cells. b Transwell assay was applied to assess the migratory and invasive capacities of PANC-1 and SW1990 cells. c The protein expression of SPRY2, β-catenin, TCF4, E-cad and VIM were detected in PANC-1 and SW1990 cells by Western blot. *P < 0.05, **P < 0.01, ***P < 0.001. ns non-significant