Table 2 Association between FOXO3a expression and clinicopathological features in PDAC patients
Clinicopathological feature | Total | Expression of FOXO3a | P value | |
|---|---|---|---|---|
High | Low | |||
130 | (n = 63, 48.5%) | (n = 67, 51.5%) | ||
Age(y) | ||||
<60 | 80 | 36 | 44 | 0.413 |
≥60 | 50 | 27 | 23 | |
Gender | ||||
Male | 75 | 39 | 36 | 0.444 |
Female | 55 | 24 | 31 | |
Tumor location | ||||
Head | 108 | 50 | 58 | 0.390 |
Body/tail | 22 | 13 | 9 | |
TNM stage (AJCC) | ||||
I | 39 | 35 | 4 | <0.001 |
II | 78 | 27 | 51 | |
III | 7 | 1 | 6 | |
IV | 6 | 0 | 6 | |
Tumor size (cm) | ||||
≤2 cm | 9 | 5 | 4 | 0.739 |
>2 cm | 121 | 58 | 63 | |
Depth of invasion | ||||
T1, T2 | 57 | 40 | 17 | <0.001 |
T3, T4 | 73 | 23 | 50 | |
Lymph node metastasis | ||||
N0 (Negative) | 79 | 56 | 23 | <0.001 |
N1 (Positive) | 51 | 7 | 44 | |
Distant metastasis | ||||
M0 | 124 | 63 | 61 | 0.044 |
M1 | 6 | 0 | 6 | |
Vascular invasion | ||||
No | 102 | 51 | 51 | 0.648 |
Yes | 28 | 12 | 16 | |
Perineural invasion | ||||
No | 117 | 59 | 58 | 0.292 |
Yes | 13 | 4 | 9 | |
Histologic grade | ||||
Well differentiation | 18 | 14 | 4 | <0.001 |
Moderate differentiation | 67 | 42 | 25 | |
Poor differentiation | 45 | 7 | 38 | |