Fig. 4
From: Glycerol kinase 5 confers gefitinib resistance through SREBP1/SCD1 signaling pathway
Downregulation of GK5 decreases mitochondrial membrane potential. a Representative histograms showing the flow cytometry analysis on JC-1 staining. b The statistical analysis on the JC-1 monomer ratio in PC9R cells compared to negative control cells incubated with 1 μM gefitinib. The data are representative of three experiments. * p < 0.05 vs. shNEG. c Western blot analysis of cleaved caspase-3, total caspase-3, cleaved PARP and total PARP protein in PC9R cells transfected with shGK5–1, − 2 or shNEG