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Table 2 Clinicopathologic factors and their effect on overall survival by univariate and multivariate Cox proportional hazards regression analysis

From: FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

Clinicopathological Features Univariate Analysis Multivariate Analysis
HRa 95%CIb P value HRa 95%CIb P value
Sex 0.809 0.313–2.088 0.661    
Age (years) 1.159 0.602–2.232 0.659    
ALT 1.770 0.684–4.577 0.239    
Tumor number 1.153 0.542–2.455 0.712    
Tumor capsule 0.617 0.319–1.194 0.151    
Serum AFP (ng/ml) 2.806 1.379–5.706 0.004 1.502 0.642–3.516 0.348
Tumor size (cm) * 3.333 1.387–8.014 0.007 2.955 1.376–6.346 0.005
BCLC stage 2.561 1.326–4.947 0.005 0.439 0.156–1.231 0.118
TNM stage 2.613 1.351–5.055 0.004 0.400 0.139–1.149 0.089
Differentiation 0.507 0.262–0.981 0.044 0.766 0.339–1.731 0.521
Vascular invasion 4.154 2.049–8.421 0.000 0.885 0.351–2.234 0.796
FBXO22 overexpression 2.275 1.036–4.996 0.041 2.357 1.077–5.157 0.032
  1. a, hazard ratio; b, confidence interval