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Table 2 Clinicopathologic factors and their effect on overall survival by univariate and multivariate Cox proportional hazards regression analysis

From: FBXO22 promotes the development of hepatocellular carcinoma by regulating the ubiquitination and degradation of p21

Clinicopathological Features

Univariate Analysis

Multivariate Analysis

HRa

95%CIb

P value

HRa

95%CIb

P value

Sex

0.809

0.313–2.088

0.661

   

Age (years)

1.159

0.602–2.232

0.659

   

ALT

1.770

0.684–4.577

0.239

   

Tumor number

1.153

0.542–2.455

0.712

   

Tumor capsule

0.617

0.319–1.194

0.151

   

Serum AFP (ng/ml)

2.806

1.379–5.706

0.004

1.502

0.642–3.516

0.348

Tumor size (cm) *

3.333

1.387–8.014

0.007

2.955

1.376–6.346

0.005

BCLC stage

2.561

1.326–4.947

0.005

0.439

0.156–1.231

0.118

TNM stage

2.613

1.351–5.055

0.004

0.400

0.139–1.149

0.089

Differentiation

0.507

0.262–0.981

0.044

0.766

0.339–1.731

0.521

Vascular invasion

4.154

2.049–8.421

0.000

0.885

0.351–2.234

0.796

FBXO22 overexpression

2.275

1.036–4.996

0.041

2.357

1.077–5.157

0.032

  1. a, hazard ratio; b, confidence interval