Fig. 3

miR-205 enhances PCa xenograft response to radiation therapy. DU145 cells stably transfected with miR-205 or Neg vector (1 × 10⁷) were implanted subcutaneously into the right flank of SCID mice. When tumors reached ~ 100 mm³, mice were randomly assigned to four groups (8 mice/group) and treated with 5 Gy single dose irradiation locally delivered to the tumor. (a) qRT-PCR showing miR-205 amount normalized to RNU-48 in Vec miR-205-tumours, compared to control ones. (b) Tumor growth volume (mm³) measured with a Vernier caliper on indicated days after cell injection. (c) Kaplan-Meier plot of mouse tumor growth to 1000 mm³